diethyl 2-{[2-(trifluoromethoxy)anilino]methylidene}malonate
2-Bromo-4-fluorophenol
CAS: 496-69-5
Molecular Formula: C6H4BrFO
diethyl 2-{[2-(trifluoromethoxy)anilino]methylidene}malonate - Names and Identifiers
| Name | 2-Bromo-4-fluorophenol |
| Synonyms | 2-BROMO-4-FLUOROPHENOL 2-Bromo-4-fluorophenol 2-bromo-4-fluoro phenol Phenol,2-bromo-4-fluoro- 2 - broMine phenol - 4 - fluorine diethyl 2-{[2-(trifluoromethoxy)anilino]methylidene}malonate Diethyl ({[2-(trifluoromethoxy)phenyl]amino}methylene)malonate diethyl ({[2-(trifluoromethoxy)phenyl]amino}methylidene)propanedioate Propanedioic acid, 2-[[[2-(trifluoromethoxy)phenyl]amino]methylene]-, diethyl ester |
| CAS | 496-69-5 |
| InChI | InChI=1/C15H16F3NO5/c1-3-22-13(20)10(14(21)23-4-2)9-19-11-7-5-6-8-12(11)24-15(16,17)18/h5-9,19H,3-4H2,1-2H3 |
diethyl 2-{[2-(trifluoromethoxy)anilino]methylidene}malonate - Physico-chemical Properties
| Molecular Formula | C6H4BrFO |
| Molar Mass | 191 |
| Density | 1.744 |
| Melting Point | 43-45 °C (lit.) |
| Boling Point | 89 °C/1 mmHg (lit.) |
| Flash Point | 185°F |
| Vapor Presure | 7.12E-05mmHg at 25°C |
| Appearance | Crystalline Solid |
| Color | Light brown to brown |
| BRN | 2355593 |
| pKa | 8.44±0.18(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.554 |
| Physical and Chemical Properties | Light yellow solid. |
diethyl 2-{[2-(trifluoromethoxy)anilino]methylidene}malonate - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3276 |
| WGK Germany | 3 |
| HS Code | 29071990 |
| Hazard Note | Irritant |
| Packing Group | III |
diethyl 2-{[2-(trifluoromethoxy)anilino]methylidene}malonate - Reference Information
| introduction | 2-bromo-4-fluorophenol is an organic intermediate, which can be obtained by bromination of p-fluorophenol or demethoxy from 2-bromo-4-fluoroanisole. 2-Bromo-4-fluorophenol can be used to prepare 3-amino-4-fluorophenol. 3-amino-4-fluorophenol is a commonly used organic chemical intermediate, which is commonly used to synthesize liquid crystal compounds, pharmaceutical compounds and intermediates of pesticide compounds. |
| 200g(1.785mol) of p-fluorophenol and 300ml of dichloroethane are added into the reaction bottle of | 2L, after mixing, 300g(1.875mol) of bromine and 150ml of dichloroethane are added dropwise at 5 ℃ ~ 10 ℃, and the temperature is kept for reaction for half an hour after dropping. Add 33g(0.26mol) of sodium sulfite and 200ml of water mixed solution, stir for 30min, let stand and layer, take the organic layer, adjust to neutral with mixed alkali solution (10% NaOH/20% NaHCO3), dry with anhydrous magnesium sulfate, and evaporate with a rotary evaporator to remove the solvent to obtain 343g (1.6888 mol) of yellow liquid 2-bromine -4-fluorophenol. Molar yield: 95%, the purity determined by gas chromatography is 94%. Boiling point 145 ℃/20mmHg. |
| chemical properties | light yellow solid. |
Last Update：2024-04-09 01:59:58
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View History
diethyl 2-{[2-(trifluoromethoxy)anilino]methylidene}malonate
HolmiumbromideanhydrousREOoffwhitepowder
1-(1H-苯并[D]咪唑-2-基)-2-苯基乙烷-1-胺盐酸盐
3-甲氧基-4-乙氧基苯甲醇
1,1′-双(二-叔丁基膦基)二茂铁二氯合钯(II)
顺式-2-叔丁氧羰酰胺环己羧酸
Sulfo Cy3 Carboxylic acids(methyl)
HolmiumbromideanhydrousREOoffwhitepowder
1-(1H-苯并[D]咪唑-2-基)-2-苯基乙烷-1-胺盐酸盐
3-甲氧基-4-乙氧基苯甲醇
1,1′-双(二-叔丁基膦基)二茂铁二氯合钯(II)
顺式-2-叔丁氧羰酰胺环己羧酸
Sulfo Cy3 Carboxylic acids(methyl)